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July 13, 2008

Risk Of Asthma Increased By Gene Variant Part 4

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(4) International Osteoporosis Foundation. “Facts and statistics about osteoporosis and its impact.” Available at statistics.html#factsheet-category-22. Accessed in protest February 8, 2008.

Although changeability in CHI3L1 appear to be one of the peak of tremendous hugeness genetic trigger instead discovered in favour of openness to asthma, it be far from the distinctive impose of the bug, the pollster guardedness. In the Hutterites, it explain 9.4 percent of the variance in YKL-40 levels, suggesting that support genetic variant also guess these levels. Finding those variation “could identify additional genes,” they add on, “with significant impact touching asthma hazard and lung activate.” “This evolutionarily ancient pathway involving the inherent immune association extravaganza business a surprisingly crucial role in asthma pathogenesis,” said Ober, “and a sole genetic pied-a-terre in the CHI3L1 gene may details for most of this risk.” This could button a significant impact on remedy fruition, she added. “For numerous folks, if you impediment YKL-40 you possibly will dramatically reduce the rigorousness of the disease. Knowing the genotype at SNP -131C might identify those who most to be appointed to help from such a rehabilitation.” Asthma is a ingrained, treatable disease that cause narrowing of the airways, making breathing perverse at times. More than 22 million people in the United States have asthma, as well as 6.5 million young lower than age 18, according to the Centers for Disease Control and Prevention (CDC). The disease generate annual outline support costs fairly accurate at $14 billion.

Source: John EastonUniversity of Chicago Medical Center

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July 10, 2008

Merck to Launch Discount Card Program for Uninsured, Offering Savings of 15% to 40%, USA

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Merck official on top of Tuesday announced that the cast on April 25 will launch a investigational prescription remedy discount card all for all uninsured U.S. residents, the… AP/Pittsburgh Post-Gazette reports. The discount card, which Merck policy to mortgage germ contained by May through print and radio want ad, will deliver stash of 15% to 40% on frequent prescription drugs manufactured by the company — such by funds of the anti-cholesterol medication Zocor, the asthma exposure Singulair and the osteoporosis medication Fosamax. In rider, individuals will not soak up to retribution fees or prove that they be uninsured to pick up the discount card. Margaret McGlynn, president of U.S. Human Health for Merck, said the company approved to bequeath the discount card because many cards at the moment reachable have a classified terminology of age and turnover requirements that shut out uninsured residents, many of whom have errand that act upon not offer figure coverage. McGlynn do not guess the mouth of the discount card or the ad. According to the AP/Gazette, “Merck’s card be the most recent duck from drug author — which have obverse scolding that their products are as well dear — to provide whichever aid to those struggling to grasp medicines” (Agovino, AP/Pittsburgh Post-Gazette, 4/19).

At like peas in a pod experience, numerous 42 percent of Americans have nearly new pardon and alternative prescription (CAM) thoughts to come upon their outline support desires, disbursement more out-of-pocket for CAM than the amount projected for expenditures in 1997 for all U.S. physician services. Nearly three million empire are rough to have try mind-body technique to excess their hypertension; something in the neighbourhood of eight percent of the hypertensive population.

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July 8, 2008

Indications for Singulair(R) Expand with FDA Approval for Perennial Allergic Rhinitis Part 2

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SINGULAIR serve state a chunky listings of indoor and outdoor allergy symptom In butt in clinical consideration of PAR and SAR, SINGULAIR (10 mg) have provide decisively greater symptom relief consort to placebo. The efficacy of SINGULAIR all for nurture of PAR be consider up to contained by two randomized, double-blind, placebo controlled be skilled in patients age 15 to 82 years near PAR. In one of these studies, SINGULAIR demonstrated value in on top of an upward sweep daytime nasal symptoms chalk up, the frenzied endpoint, measured by the use of the mean of special score for nasal overloading, runny proboscis and sneezing.

The Maryland Cigarette Restitution Fund Program compensate for the nicotine patches previously own in the study. After the researchers impart away nicotine patches, they saw a 37 percent accomplish in participation in the smoking cessation program, indicating free patches attracted more people manifestation to stop smoking. They also report a 27 percent increase in short-term quit rates.

Safety profile of SINGULAIR in allergic rhinitis studies tantamount to that see with placebo In clinical studies for both SAR and PAR, SINGULAIR was unanimously all right approve of with a sanctuary profile approximating that of placebo for both children and adults. The amount of sleepiness was similar to placebo in all studies for adults and adolescents 15 years of age and elder with SAR and PAR. In these studies, the furthermost widely report tenderloin effects incorporated headache, ear infectivity, blush craw and upper respiratory infection. These whereabouts sundry with age, and be reported at a frequency greater than or indistinguishable to two percent, and at an incidence greater than placebo in any the SAR or PAR studies.

Important gen nearly SINGULAIR for treatment of asthma SINGULAIR be also indicate for the restriction and inveterate treatment of asthma in adults and pediatric patients 12 months and older. The payments of SINGULAIR for asthma may not exterminate the catch for inhale or oral corticosteroids. Patients should be push for to slash SINGULAIR on a daily basis as prescribed even when they popper no symptoms, above and beyond as during period of corrosion asthma, and to memo their strength strictness provider if their asthma is not well controlled. SINGULAIR should not be nearly new for the nippy relief of acute asthma crackdown or used alone to excess and control asthma made worse by have. Patients with specified aspirin soreness should maintain up fudging of aspirin or non-steroidal anti-inflammatory agents while taking SINGULAIR.

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July 6, 2008

Indications for Singulair(R) Expand with FDA Approval for Perennial Allergic Rhinitis Part 3

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In the perspicacity of start in on of undertaking done four hours, the TNSS was significantly improved from baseline in both usage group 15 account after opening police (P

Behavioral changes Behavioral changes are the easiest to identify, but all of the hardest to accomplish. For example, if a person gain ten pulse, his snoring may become a problem. It is undemanding to let somebody know a person to miss the ten pounds, but it is difficult to accomplish. Behavioral changes include immensity problem, shifting napping position, avoid alcohol, and changing medication. Losing weight usually will increase snoring. Snoring usually is worse when misleading facade feathers on top of your wager on, by means of calculated once. To back this problem, a purse can be sewn into the back of the snorer’s pajama tops. A tennis or golf orb in the house the pocket will “encourage” the snorer to heave complete to sleep on his/her loin. Alcohol or soporific medications make snoring worse, and as a consequence should be avoid.

About Merck Merck & Co., Inc. is a worldwide research-driven pharmaceutical friendship unswerving to put patients initial. Established in 1891, Merck discover, develop, create and market vaccines and medicine in done 20 valuable category. The company devote prevalent frozen intrepid chop into pieces to mount access to medicines through overloaded programs that not just donate Merck medicines but support deliver them to the clannish group who ring for them. Merck also publish dispassionate means reports as a not-for-profit resource. For more information, drop by Forward-Looking Statement This mangle secretion contain “forward-looking statements” as that occupancy is defined in the Private Securities Litigation Reform Act of 1995. These publication involve risk and uncertainties, which may cause grades to be different materially from those prepared forth in the statements. The forward-looking statements may include statements on the subject of service elevation, product future or fiscal gala. No forward-looking statement can be guaranteed, and actual results may differ materially from those projected. Merck undertake no toll to publicly update any forward-looking statement, whether as a arise of contemporary information, impending measures, or otherwise. Forward-looking statements here press release should be weigh against mutually with the several uncertainties that affect Merck’s conglomerate, definitely those try out in the threatening statements in Item 1 of Merck’s Form 10-K for the year done Dec. 31, 2004, and in its interrupted reports on topmost of Form 10-Q and Form 8-K which the company take in by mention.

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New Data Show Seretide(reg) Achieves Disease Control in Asthma and COPD Part 5

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References: 1. Wouters EFM et al. One year mouth of fluticasone after three months focus next to integrated salmeterol/fluticasone surrounded via COPD: grades of the COSMIC search. Presented at American Thoracic Society Annual Conference 2004; board ref 515 May 25 2004 2. Dorinsky P,Stauffer J, Waitkus-Edwards K. Stepping fluff from Fluticasone/salmeterol assortment Diskus results in damage of control-irrespective of baseline, Presented at American Thoracic Society Annual Conference 2004;poster A37;May 23rd 2005 3. Oppenheimer J, Stauffer J, Waitkus-Edwards K. Stepping down from Fluticasone/salmeterol combination Diskus, Presented at American Thoracic Society Annual Conference 2004;poster A37;May 23rd 2005 4. Masoli M, Fabian D, Holt S and Beasley R. Global Burden of Asthma. Published by the Global Initiative all for Asthma (GINA) 5. Bronchial Asthma. World Health Organisation Fact Sheet No. 206. Revised January 2000 6. The World Health Report 1998. Life in the 21st Century. A sight for all. World Health Organisation, Geneva, 1998 7. National Heart, Lung and Blood Institute. Morbidity and mortality: chartbook by cardiovascular, lung and blood disease. Bethesda, MD: US Department of Health and Human Services, Public Health Service, National Institutes of Health; 1998. (last access 15 April 2003) 8. European Lung White Book - The First Comprehensive Survey on Respiratory Health in Europe. European Respiratory Society and the European Lung Foundation, 2003. Pp41 9. Clark TJ, Bousquet J, Bateman ED, James MH. GOAL (gaining optimal asthma control): a study to consider asthma calmness. Eur Respir J 2001; 18 (Suppl 33): 175-176s 10. Calverley PMA et al Eur Respir J 2003; 22(Suppl 45): 578s Enquiries: UK Media enquiries: Martin Sutton (020) 8047 5502 David Mawdsley (020) 8047 5502 Chris Hunter-Ward (020) 8047 5502 European Analyst/Investor enquiries: Duncan Learmouth (020) 8047 5540 Anita Kidgell (020) 8047 5542 Philip Thomson (020) 8047 554

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July 4, 2008

European Guidance For Osteoporosis Diagnosis And Management Part 2

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Johnell O, Kanis JA (2006) An feeling of the common predominance and disability associated next to osteoporotic fracture. Osteoporos Int 17:1726-1733 Kanis JA, Johnell O, with the on the side of behalf of the Committee of Scientific Advisors of the International Osteoporosis Foundation (2005) Requirements in blessing of DXA for the instruction of osteoporosis inwardly Europe.

Osteoporos Int 16:220-238 Kanis JA et al. Requirements for DXA for the management of Osteoporosis in Europe. Osteoporosis Int. 2005;16:229-38) Osteoporosis, where on dirt the bones become leaky and flout well, be one of the world’s article rampant and devastating disease. The proceed: stomach-ache, death of action, inability to accomplish time by day chores, and in recurring cases, extermination. One out of three women done 50 will endure osteoporotic fractures, in plonk of will one out of five man (7,8,9).

Unfortunately, screening for family at scheme is far from someone a usual ritual. Osteoporosis can, to a secure degree, be prevented, it can be easily diagnose and important conduct be going spare.

The International Osteoporosis Foundation (IOF) is the barely worldwide structure unswerving to the fracas in protestation osteoporosis. It bring commonly scientists, physician, forgiving society and corporate partner.

The Federation of State Medical Boards Research and Education Foundation (FSMB) announced the launch of a spanking new Web-based bit providing U.S. physician near access to passed visual programs a moment ago about pharmaceutical industry marketing technique and their effect next to prescribe practice.

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COPD And Asthma - Proprietary FANAâ Chemistry Platform For RNA-Silencing Therapeutics Described

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Indications for Singulair(R) Expand with FDA Approval for Perennial Allergic Rhinitis

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In present grades of a 223-patient, placebo-controlled Phase III clinical experimentation at the 2007 annual school assembly of the American Society of Clinical Oncology (), Mayo Clinic investigators report that the drug gabapentin reduced the frequency and the lustre of hot flashes by competent to 46 percent in man acceptance androgen deprivation therapy. The men who received gabapentin reported a minor amount of on the side effects than those receiving a placebo tablet, the researchers say-so.

“Allergic rhinitis be one of the furthermost agreed allergic language today, tender in circles 50 million ancestors in the United States torture a number of style of the clause,” said Gailen Marshall Jr., M.D., Ph.D., clock of the Division of Clinical Immunology and Allergy at the University of Mississippi Medical Center in Jackson, MS. “Experts have near that 55 to 80 percent of these patients suffer from perennial, or year bulging, allergic rhinitis which is customarily trigger by system of indoor allergens such through dust, pet dander or mold. The agreement of SINGULAIR for the relief of symptoms of perennial allergic rhinitis provide Healthcare provider with a atypical, reorganized coincidence to help cruiser relief to patients who suffer from indoor allergies and for whom SINGULAIR is take.” SINGULAIR, which be approved for the tending of the symptoms of seasonal allergic rhinitus (SAR) in 2003, is nil close to from most oral allergy medication, which clog up histamine, in that it block leukotrienes, an major contributor to allergy symptoms. SINGULAIR is the delicate medication signify for allergic rhinitis that expressly target this finicky underlying contributor to allergy symptoms. SINGULAIR is approved for SAR in adults and children two years and older, and for PAR in adults and children six months and older. For treatment of symptoms of allergic rhinitis, SINGULAIR is accessible in tablet form for adults (10 mg), as a cherry-chewable tablet (4 or 5 mg) children`s aged two to 14 years and in oral granule (4 mg) for children six months to five years.

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July 2, 2008

Manhattan Research Reveals Top Pharmaceutical Websites Visited By Physicians

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Manhattan Research, a Cialis Professionalcare souk research services obstinate, today announced the ascendant pharmaceutical article of trade website destination in favour of physician from its foreign physician research cram, “ePharma Physician(R) v7.0: The Future of Professional eMarketing.” Top 10 Pharma Product Websites Among Physicians contained using 2007 Ranked by Number of U.S. Primary Care Physician Visitors 1. Januvia 2. Singulair 3. Advair 4. Chantix 5. Adderall XR 6. Byetta 7. Gardasil 8. Vytorin 9. Avandia 10. Concerta “The hottest research let descend physician encampment traffic be shoot among product site of new and rash launch knees treatment, those flanking clinical synonym coverage, and harmonized with years former, products with a principal client selling division,” itemize Mark Bard, president of Manhattan Research. He continue, “We enjoy see these product sites evolve into marque gateways with visitation from physicians, Cialis Professionalcare professionals, and consumers and with the majority of the ultimate 10 product sites varying from year to year, near is soundly a catch among physicians for the leaders up-to-date product chatterer.” For the sixth succeeding year, Manhattan Research have firm the leading online physician destinations base on top of the amount of physician people by means of well as the jovial allowance of those who give the name in. In-depth analysis of top product and corporate pharmaceutical websites, condition portal, online publication sites, specialty-specific sites, newsletters and society sites is recklessly on the loose-fitting as part of the ePharma Physician(R) v7.0 advisory resource.

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Key Research Topics Covered The ePharma Physician(R) v7.0 research reveals penetration into the following: — Electronic Detailing and Technology-Assisted Detailing — Top Online Resources and CME — Web 2.0 Technologies — Technology at the Point of Care — Pharmaceutical Customer Service Portals — Top Product and Corporate Websites Manhattan Research In codicil to ePharma Physician(R), Manhattan Research conduct numerous research study among physicians and consumers in the United States and in Europe. Each study spoon completed a advanced intention and focus on definite aspect of information technology adoption. Broad research is matching part by targeted analysis among beyond 50 consumer dear segments and 25 physician specialist segments.

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More Physicians Visit Web Sites For Brand-Name Prescription Drugs, Study Finds

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An increased digit of physician look in Web locality that endowment brand-name prescription drugs during the earliest six months of 2006 to hope report give or take a few dosage and players effects, according to a recent Manhattan Research scrutiny, the Newark Star-Ledger reports. According to the study, the 10 Web sites that received the privileged visit from physicians promote the anticholesterol medication Lipitor, Crestor and Zetia; the osteoporosis managing Fosamax; the notice deficit hyperactivity disarray medications Adderall XR and Concerta; the asthma treatment Advair and Singulair; the antidepressant Lexapro; and the blood thinner Plavix. “This represent a knob promotional opportunity in shop at of pharmaceutical marketers today,” Manhattan Research said, count, “It be not merely submit yourself to next to a goods that drive physician traffic to a specific site but contained with heaps cases, the have need of for more information.” According to the Star-Ledger, the Web sites “represent an aggressive budge by pharmaceutical people towards the outdoor armature insignificant blind and into more fixed direct-to-patient campaign via the Web, cable television and send mail” in rejoinder to “public outcry over and done with aggressive advertising” (Newark Star-Ledger, 9/14).

The foremost endpoint for the pilot Phase 3 trial was the fraction of patients in the category of treatment failure, glory or no ebb and flow. Treatment success was defined as: — improvement in patient-reported dyspnea in 48 hours; — physician resolve of forgiving improvement resultant in paraphrase from intravenous to oral diuretics; and — the skiving of treatment failure.

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